DNA damage by ROS

Measurement of Oxidative DNA Damage and Repair in the Aging and Diseased Human Brain Using Liquid and Gas Chromatography/Mass Spectrometry with Isotope Dilution: "There is accumulating evidence that reactive oxygen species (ROS) play an important role in aging and neurodegenerative disease. Genomic DNA appears to be a particularly important target for ROS, since human patients and knockout mice lacking the capacity to repair certain types of [sic] oxidative DNA damage experience neurodegeneration and show evidence of premature aging."