Chemistry of Life

Molecular genetics, biochemistry

capping

Capping is a stage of RNA processing in which the 5’ end of the nascent pre-mRNA is capped with a 7-methyl guanosine nucleotide, 7-methylguanylate. Capping occurs shortly after initiation of transcription.

The 5' cap is retained in mature mRNAs. Capping is required to protect the RNA transcript from degradation. It plays an important role in mRNA transport to the cytoplasm and in the initiation of protein synthesis (translation ) .

Life Cycle of mRNA : : NCBI Molecular Cell Biology : Post-transcriptional Processing of RNAs : life cycle of HIV animation

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. . . transcription begun 10/06/06