Increased efficiency of oligonucleotide-mediated gene repair through slowing replication fork progression -- Wu et al. 102 (7): 2508 -- Proceedings of the National Academy of Sciences: "In mammalian cells, the precise mechanism of SSO-mediated chromosome alteration remains to be established, and there have been problems in obtaining reproducible targeting efficiencies. It has previously been suggested that the chromatin structure, which changes throughout the cell cycle, may be a key factor underlying these variations in efficiency. "
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